Endocrine Abstracts

Recent studies have shown that serum concentrations of AMH (produced by granulosa cells of the human ovary) are positively related to the number of antral follicles and are negatively correlated with age. Like inhibin B (also a granulosa cell product) AMH is thought to be a useful clinical marker of follicle reserve. Serum AMH concentrations have been reported to be higher than normal in women with polycystic ovary syndrome (PCOS), which is characterised by an excess of antral...

Anti-Mullerian hormone (AMH) is expressed in the ovary, in granulosa cells (GC) of preantral and antral follicles. Mice lacking the AMH gene show an increase in the proportion of early growing follicles and a reciprocal decrease in the primordial pool, suggesting an important role in early follicle growth. Little is known about the expression of AMH in the human ovary. Recent studies have shown that the proportion of follicles entering the growing pool is increased in PCO, sim...